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After thirty minutes or so I felt calmer, and started to feel effects of the medication. Steven Cooper at the University of Birmingham found that he could block the ability of benzodiazepines to reduce anxiety in rats by giving them small doses of the drug naloxone, which blocks opioids. The GABA-receptor seems to exist in two states, a high affinity state that favours its reaction with GABA, and a low affinity state that discourages the binding of GABA. A later study did not confirm this finding, and this question remains open. Ironically, the benzodiazepines make it more difficult to learn alternative strategies for coping with stress, such as behavioural treatment for agoraphobia.
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